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Major roles and biological functions of manganese

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  • Lumen
Category
  1. Nervous system

1. Protection of the nervous system and detoxification of neurotransmitters

Manganese is very important for maintaining the normal functions of the brain and nervous system and for forming nerve tissue.
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In particular, manganese acts as an essential catalyst that activates 'glutamine synthetase' in the brain . This enzyme is a versatile enzyme that detoxifies the excitatory neurotransmitter 'glutamate' and the toxic substance 'ammonia' by converting them into safe glutamine or the sedative neurotransmitter GABA.
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Therefore, sufficient manganese is necessary to prevent brain nerve cells from becoming overexcited or exposed to toxicity, which in turn prevents epileptic seizures and maintains mental well-being.

2. Powerful antioxidant action (mitochondrial protection)

Mitochondria, the energy factories within cells, inevitably produce reactive oxygen species during the process of generating energy.
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Manganese is a key component of 'Superoxide dismutase (SOD),' the highest level antioxidant enzyme that defends mitochondria from damage caused by these free radicals .
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Only when SOD is activated through manganese can it prevent cellular aging and oxidative stress and form a protective barrier against disease.

3. Activation of energy metabolism enzymes and blood sugar regulation

Manganese promotes metabolism by activating metabolic and detoxification enzymes.
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Numerous enzymes that properly process and metabolize the carbohydrates, amino acids, and cholesterol we consume require manganese . For example, manganese is involved in the catalytic action of PEPCK, an enzyme important for the production of new glucose (gluconeogenesis) in the liver.
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As a result, manganese contributes to stabilizing blood sugar and helping with normal insulin secretion.

4. Maintaining the structural health of bones, cartilage, and teeth

Manganese is essential for forming and maintaining the skeletal system and connective tissue.
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Increased Bone Density: It helps increase bone density in the spine and other areas, and aids in delaying the progression of osteoporosis. Additionally, by contributing to the formation of bone and cartilage tissue, it is beneficial for recovering from chronic inflammation and sprains such as ligament injuries.
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Prevention of dental caries (cavities): Healthy teeth perform a self-cleaning function in which fine fluid flows from the inside (pulp) to the outside, washing away bacteria and toxins. This fluid flow is generated by cellular oxidation and energy production, and manganese, along with magnesium, copper, and iron, actively participates in this cellular oxidation process to maintain internal defenses and prevent tooth decay.

5. Immunity, DNA Protection, and Thyroid Health

Manganese plays an essential role in several enzyme systems that provide immunity to the body .
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In addition, it promotes healthy DNA and supports reproductive function and red blood cell synthesis.
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It also plays an additional role in supporting thyroid health and helping nutrients be properly absorbed in the body.
💡 To summarize:
Manganese is the key that operates the most fundamental and precise enzymes necessary for maintaining life, including metabolism, detoxification, nerve stabilization, antioxidant activity, and bone formation. Supplementing manganese through foods such as mussels, oysters, and pork belly is recommended. Manganese is crucial for defense mechanisms and regenerative systems that protect our bodies from chronic inflammation and metabolic diseases.
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